Introduction In the Nigerian health care system, the role of plants/herbs as medicines is presently well recognized, and nearly all plants are associated with medicinal uses (Anyawu and Okoye 2017). Allium sativum is widely used as a spice in Cameroon and has been investigated for its antimalarial activity. In Africa, garlic is used as an antibiotic, and it has a reputation for lowering blood pressure and cholesterol, and inhibiting thrombus formation (http://uses.plantnet-project.org/en/Allium_sativum_%28PROTA%29). Excellent in the treatment of diarrhea, and a treatment for bacterial, fungal and viral infections. HPLC-mass spectroscopy was used to analyze chlorogenic acid, ferulic acid, vanillin, kaempferol, gallic acid, quercetin, and ellagic acid. Our expert typically replies in a few minutes. Search by keywords . [99] isolated ajoene (36) from this plant, which reduced considerably the severity of P. berghei infection in mice and was nontoxic. Despite some disagreements from scientists in studying the antihyperglycemic mechanism of garlic, one thing all researchers would agree on is that the safety profile and bioactivity of garlic in other disease models has allowed it to be used in an impressive number of human studies. Titanji, in Medicinal Plant Research in Africa, 2013. M.S. Preparation of garlic extraction includes soaking of fresh garlic pieces in cold water for about 12 hours, followed by boiling. garlic extract The alcoholic extract of the bulb or whole garlic plant Allium sativum (Liliaceae) with potential antineoplastic activity. Essential rosemary oil protects testicular cells against DNA-damaging effects of H. Garlic is known to contain many chemical compounds that may influence both the pharmacokinetic and pharmacodynamic behaviors of prescription drugs. In Moderate hypertension with moderate hyperlipidemia, and in the upper respiratory tract infections (URTI). Garlic extract contains allicin, a chemical that may help boost the immune system. Various Ayurvedic practitioners and sages have considered garlic a good carminative for digestive problems. It is native to Central Asia and northeastern Iran and has long been a common seasoning worldwide, with a history of several thousand years of human consumption and use. Garlic is rich in antioxidants which help destroy free radicals. Nature has ingeniously packaged a chemical factory in garlic. To this end, synergistic pharmacodynamic effects were observed after the administration of garlic and/or garlic-containing supplements in combination with fluindione, chlorpropamide, and nonsteroidal antiinflammatory drugs (NSAIDs) (Berginc and Kristl, 2013; Piscitelli et al., 2002). The cloves have a characteristic pungent, spicy flavor that mellows and sweetens considerably with cooking. ALLIUM SATIVUM (GARLIC) BULB EXTRACT, ALLIUM SATIVUM (GARLIC) EXTRACT, ALLIUM SATIVUM EXTRACT, EXTRACT OF ALLIUM SATIVUM, EXTRACT OF GARLIC, GARLIC EXTRACT, and GARLIC, EXT. Allium Sativum Bulb Extract is an extract of the bulb of the Garlic, Allium sativum L., Liliaceae 19. By lowering lipids in the blood (such as cholesterol and triglycerides) it benefits the heart. Examining the formation of 8-OH-dG in calf thymus DNA incubated with CrCl3 and H2O2. 19 Cosmetics Ingredients containing ALLIUM SATIVUM BULB EXTRACT. This study reported that no insulin response could be measured (Sitprija et al., 1987). In the First World War, garlic was widely used as an antiseptic. Since antiquity, garlic is one of the most important medicinal and culinary plants and finds mention in the various traditional and folk systems of medicine. The bulb of the plant is the most commonly used part and is divided into numerous fleshy sections called cloves. 627, JLPL, Industrial Area, Sector-82, Mohali-140306, Punjab (India). [Smell] rich and pure smell of Garlic . S.L. The health benefits of garlic are varied and many. The allium sativum extract are derived from appropriate plants that have been studied and … † Garlic extract is also rich in nutrients such as allinase, myrosinase, peroxidase, various B vitamins, vitamin C, iron, zinc, and copper and is loaded with antioxidants. A few case reports indicated that the ingestion of garlic in combination with warfarin may increase the INR; however these are inconsistent, because other studies reported no effect. 1-2 capsules, twice daily with plain water after meals. Nutrit Res 1990;10:937-948. The wide selection of allium sativum extract guarantees that you will get a product of your choice whether you’re buying it for yourself, your loved ones, or your friends. One study showed a significant reduction in plasma levels, as well as the mean area under the curve (AUC) of saquinavir after coadministration of a garlic product for 3 weeks. Extracts from garlic are reported to have a number of biocidal activities, to decrease lipid and cholesterol levels, to prolong clotting times, to inhibit platelet aggregation, and to increase fibrinolytic activity.30,31 Acute toxicity of allicin for dogs and cats is unknown; its LD50 for mice following subcutaneous or IV administration is 120 mg/kg and 60 mg/kg, respectively. One study went as far as to claim the aqueous extract was not statistically effective in reducing hyperglycemia in a glucose tolerance test, but decreased the peak value during a spike (Bordia et al., 1998), a very interesting mechanism should it prove to be true. Description : Allium Sativum Extract ( Garlic Extract )is used for many conditions related to the heart and blood system. Pai Department of Microbiology, University of New Mexico, School of Medicine, Albuquerque, NM 87131, USA Garlic (Allium sativum) is a very powerful medicinal plant (or, more accurately, a functional food) that is often underestimated. The composition of Allium bulbus is complex. How Evans Syndrome can be Managed by Natural Remedies? OQEMA. Buy amazing allium sativum extract on Alibaba.com at irresistible offers and enhance your well-being. Antifungal effect of Allium sativum (garlic) extract against the Aspergillus species involved in otomycosis. This result suggests that the mechanism by which glucose is brought out of the blood is independent of insulin concentration. Garlic extracts have been found to be very beneficial in many types of the cardiovascular disorders and it is found to be having a very beneficial effect in the cases of hypertension and high lipid profile cases. Not all of these studies have shown promising results. LEs also showed better results than the other extracts in terms of protein oxidation, OH-induced deoxyribose degradation, lipid peroxidation inhibition, and superoxide anion-scavenging capabilities. Figure 11.5. Despite these discouraging results, there are two human studies that have shown antidiabetic activity. These results suggest that strawberry has photoprotective activity and may protect skin against the adverse effects of UVA radiation. Garlic is widely used as a medicine worldwide and is regarded as an aphrodisiac (http://www.kew.org/science-conservation/plants-fungi/allium-sativum-garlic). Antifungal effects of Allium sativum (garlic) extract against the Aspergillus species involved in otomycosis S.T. Spiritual uses have been assigned to garlic; in fact, it was reported that garlic could be worn, hung in windows, or rubbed on chimneys and keyholes to ward off vampires. These herbal capsules have a significant protective action against a fat induced increase in serum cholesterol and plasma fibrinogen. Probably because of this, the species has been run through a gauntlet of antidiabetic assays. Each capsule of Garlic contains standardized extract of Garlic (Allium sativum) herb, packed in pure vegetarian and gelatin free capsule shells. This small book is an introduction to Ayurveda, written by Dr. Vikram Chauhan - MD (Ayurveda). Aim: The objective of this in vitro study was to assess the antibacterial effect of different concentrations of garlic extract against human dental plaque microbiota. Furthermore, pharmacokinetic interactions have been observed when garlic is administered in combination with acetaminophen and lisinopril (Berginc and Kristl, 2013; Piscitelli et al., 2002). The hypotensive effects are found to be very multifactor, and include the ability of Garlic extracts to inhibit PAF. In chronic toxicity studies with garlic oil or garlic extracts, anemia has been observed in dogs. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL: https://www.sciencedirect.com/science/article/pii/B9780128092866000157, URL: https://www.sciencedirect.com/science/article/pii/B9780123971531000159, URL: https://www.sciencedirect.com/science/article/pii/B9780128163337000102, URL: https://www.sciencedirect.com/science/article/pii/B9780124059276000175, URL: https://www.sciencedirect.com/science/article/pii/B9780123964854000311, URL: https://www.sciencedirect.com/science/article/pii/B9781455707171000260, URL: https://www.sciencedirect.com/science/article/pii/B9780323029988500160, URL: https://www.sciencedirect.com/science/article/pii/B9780128054130000284, URL: https://www.sciencedirect.com/science/article/pii/B9780123971531000421, URL: https://www.sciencedirect.com/science/article/pii/B978012811519000011X, Medicinal Spices and Vegetables from Africa, http://uses.plantnet-project.org/en/Allium_sativum_%28PROTA%29, http://www.kew.org/science-conservation/plants-fungi/allium-sativum-garlic, Bioactive Food as Dietary Interventions for Diabetes, Antimalarial and Other Antiprotozoal Products from African Medicinal Plants, Denis Zofou, ... Vincent P.K. In an experiment, 10% garlic extract was used for soaking hand-picked oranges for a period of about 10–15 minutes, dried in air, and packed boxes with some empty cases and hardboards. The results showed that these extracts could significantly inhibit the OH-dependent damage of pUC18 plasmid DNA. it helps to provide the strength to or it boosts the immune system. Oral LD50s for garlic extracts, given by various routes to rats and mice, range from 0.5 mL/kg to 30 mL/kg. Burcu Dogan-Topal, ... Sibel A. Ozkan, in Genetically Engineered Foods, 2018. Natural products have numerous medicinal applications and play important roles in the biology of the organisms that accumulate them. Another double-blind placebo-controlled study showed a statistically significant reduction in blood glucose levels using 800 mg of dried and sugar-coated garlic bulb (Kiesewetter et al., 1991). Allium Sativum (Garlic) Extract as Nontoxic Corrosion Inhibitor K. Rajam , 1 S. Rajendran , 2 , 3 and R. Saranya 4 1 Department of Chemistry, K. L. N College of Information Technology, Pottapalayam 630 … Pierre and MiquelonSudanSurinameSvalbard and Jan Mayen IslandsSwazilandSwedenSwitzerlandSyriaTaiwanTajikistanTanzaniaThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks & Caicos IslandsTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUruguayUSA Minor Outlying IslandsUzbekistanVanuatuVatican City State (Holy See)VenezuelaVietnamVirgin Islands (British)Virgin Islands (U.S.)Wallis and Futuna IslandsWestern SaharaYemenZambiaZimbabwe. Urol Clin North Am 2000;27(1):157-162, xi. Isolation, physical properties and antibac- However, when given to infected mice the number of or- terial action. If you continue to use this site we will assume that you are happy with it. Allium sativum is a member of the onion family. In vitro synergism of concentrated allium sativum extract and amphotericin B against cryptococcus neoformans. Badole, ... N.K. Extracts from garlic are reported to have a number of biocidal activities, to decrease lipid and cholesterol levels, to prolong clotting times, to inhibit platelet aggregation, and to increase fibrinolytic activity (Siegers, 1991; DerMarderosian, 2001a). [99]. Robert H. Poppenga, in Veterinary Herbal Medicine, 2007. Microbiol. Acute toxicity of allicin for dogs and cats is unknown; its LD50 for mice following subcutaneous or intravenous administration is 120 mg/kg and 60 mg/kg, respectively. The effects were comparable to those of allicin and diclofenac. Block (1992) reported garlic as a rich source of bioactive compounds and as a folk medicine for the treatment of various diseases. Lett. The shelf life of these oranges was prolonged for up to 70 days, which was more than 92.4% at room temperature (Gao, 1990a). Allicin exhibit strong antifungal activity against anthracnose fungi, damping-off fungi, and Rhizopusnigricans . The results may vary from person to person, therefore, before using these products, consult your doctors. One study (n = 120), on garlic bulb oil, using 4 × 8 mg drops per day for 2 months, showed a statistically significant reduction of blood sugar levels (Zaman et al., 1981). However, in another study no changes in the single-dose ritonavir pharmacokinetics were observed after 4 days, when garlic was coadministered (Piscitelli et al., 2002). Flavonoids are one large group of natural products with a diverse number of functions in plants and in human health. By Qi et al., the ability of melatonin to diminish Cr (III)-induced oxidative DNA damage in vitro was studied (Qi et al., 2000). In folk medicine, garlic has been used internally to treat bronchitis and respiratory problems, gastrointestinal problems, flatulence, leprosy, menstrual cramps, high blood pressure, and diabetes, and externally for warts, corns, arthritis, muscle pain, neuralgia, and sciatica. This study indented to assess the clinical and radiographic assessment of Allium sativum extract as an intracanal irrigant for pulpectomy of primary molars. It contains also proteins (amino acids, glutamyl peptides…), glucides, enzymes (alliinase, peroxidase, myronidase…) Allicin is … We use cookies to help provide and enhance our service and tailor content and ads. When combined with the well-known safety index of garlic, and its wide availability, garlic is suitable to be utilized by the public for its various bioactive characteristics, including its antidiabetic properties. It is Antibacterial, antifungal, anti-inflammatory, antimicrobial, anthelmintic, antiseptic, antiviral, hypotensive-vasodilator, cholagogue, antispasmodic, decreases the blood cholesterol levels, increases HDL, increases fibrinolytic activity, hypoglycemic, expectorant, diaphoretic, antioxidant, antitumour, antineoplastic, antimutagenic, diuretic and carminative. It was also reported that in Islam, it is generally recommended not to eat raw garlic prior to going to the mosque, since the odor could distract other Muslims during their prayer. This study determined the compound and content of secondary metabolites and antioxidant activity from the ethanol extract of garlic (Allium sativum L.) and black garlic. Charu Gupta, Dhan Prakash, in Food Safety and Human Health, 2019. Garlic has a long history of medicinal use for a wide variety of conditions and was once known as the poor man's treacle. Ameliorative Effects of Allium sativum Extract on iNOS Gene Expression and NO Production in Liver of Streptozotocin + Nicotinamide-Induced Diabetic Rats Indian J Clin Biochem. HPLC-EC was used to detect 8-OH-dG and the authors found that the oxidative DNA damage was reduced by 50% when using 0.51, 30.4, and 36.2 μM of melatonin, ascorbate, and vitamin E respectively. The proven health benefits of allium sativum extract will leave you with a smile. Perez et al. This is useful for students, general public and people interested in natural remedies, yoga and herbs. In addition, garlic is well known to have antimicrobial activities and may reduce intestinal flora, thereby reducing the production of vitamin K in the gut, possibly potentiating the effects of anticoagulants such as warfarin. garlic extract (Allium sativum). Data represent means ± SD of 3–5 isolations. 15.1). The plant contains 0.1% to 0.3% of a strong-smelling, volatile oil containing allyl disulfides, such as allicin. Pure and natural Garlic supplements are available in the form of Capsules and can be purchased at Planet Ayurveda. It supports the heart and cardiovascular system may help in maintaining healthy cholesterol and glucose levels when taken … The authors found that the organosulfur compounds reduced DNA SBs and that DAS and DPDS (5 μM) had protective effects against DNA SBs (37 and 35%, respectively). The present study, the methanolic extracts from the Sveva cultivar for their anthocyanin content and their ability to protect human dermal fibroblasts against UVA radiation using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenytetrazolium bromide and the comet assays (Giampieri et al., 2012). A. sativum reduced serum total oxidative status, malondialdehyde and nitric oxide production, and increased total thiols. Veterinary herbal medicine, 2007 different forms such as cholesterol and plasma fibrinogen helps to provide the to... The sensitivity of cat hemoglobin to oxidative damage may make cats more sensitive to adverse effects hours followed!, consult your doctors significantly reduced the levels of both DNA breaks and oxidative DNA damage was induced an! Compounds that may help boost the immune system were significantly lower in rats with! The results showed that these extracts could significantly inhibit the formation of 8-OH-dG in calf thymus DNA with... 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